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Cosby | TN - Commercial Real Estate

Discover excellent opportunities with commercial real estate for sale or lease in Cosby, TN. Located at the gateway to the Great Smoky Mountains, Cosby offers a strategic location for businesses serving both local residents and the steady stream of visitors traveling to Gatlinburg, Newport, and surrounding East Tennessee communities.

Commercial properties in Cosby range from retail storefronts and office buildings to warehouses, hospitality venues, and multi-use spaces. Whether you’re a small business owner looking for a visible location, an investor seeking income-producing property, or a company in need of flexible lease options, Cosby delivers a variety of opportunities.

With its scenic mountain setting, growing residential base, and strong tourism traffic, Cosby is well-positioned for retail, dining, lodging, and service-based businesses. Easy access to U.S. Highway 321 and nearby interstate routes makes this community an appealing hub for both local and regional commerce.

4925 Hooper Highway, Cosby $1,300,000 ▼

A unique live-work opportunity on 1.3 acres along Highway 321 in East Tennessee, 4921 Hooper Hwy combines a 2-bedroom, 2-bath residence with 3,172 square feet of finished...

1.3 Acres
713160 MLS
ACTIVE Status

4925 Hooper Hwy, Cosby $1,300,000 ▼

A unique live-work opportunity on 1.3 acres along Highway 321 in East Tennessee, 4921 Hooper Hwy combines a 2-bedroom, 2-bath residence with 3,172 square feet of finished...

1.3 Acres
3602898 MLS
ACTIVE Status

3925 Cosby Hwy, Cosby $219,000

Prime opportunity to acquire this commercial property at the busiest intersection of Hwy 321 and Jones Cove Road, offering endless possibilities, including a deli, coffee...

0.56 Acres
3548471 MLS
ACTIVE Status

Equal Housing Opportunity. All information contained herein deemed reliable but not guaranteed. Buyers should personally verify all information. All content Copyright 1998-2026 Great Smoky Mountains Association of Realtors. All rights reserved. Last updated .

Information Is Believed To Be Accurate But Not Guaranteed. Some or all listings may or may not be listed by the office/agent presenting these featured properties. Copyright 2026 MTRMLS, Inc. RealTracs Solutions.